One of its projects was a weapons project entitled Project Meta. Using a sample of Clayface mud bought from a Gotham Rogues collector and a radiation source from Egypt, they intended to reconstruct Clayface's cellular structure to suit their needs. They went as far as obtaining weapons for their scientists to protect against industrial espionage. At some point, Penguin caught wind of it and sent Deadshot to investigate, unaware that Deadshot was working under the orders of Amanda Waller. Deadshot then enlisted Batman's aid and the two of them assaulted a Stagg Industries building, knocking out the security and facing off against one of its well-armed scientists. In the ensuing shootout, the Clayface Mud sample was able to escape.
The company entered an alliance with Scarecrow to develop an improved version of Fear Toxin. Shortly after Scarecrow's escape, Stagg ended up apprehended by the GCPD for his involvement in Scarecrow's plan. The recording of Stagg's canisters in the GCPD Lockup Evidence Room also implied that the company would suffer immensely for their role in Scarecrow's plan, with Aaron Cash stating that the canister "won't be the only thing confiscated from Stagg Enterprises tonight."
- Stagg Enterprises as well as its CEO were not native to the Batman Comics, but they were the main antagonists of the DC Comics franchise, Metamorpho.
- One of the victims of Professor Pyg in the Gotham's Most Wanted Side Mission, The Perfect Crime, Robert Kincaid, was a former microbiologist at the company, although he presumably fled after he was nearly made an assassination victim, presumably by Stagg to cover up some unethical research.